Concentration of Hyaluronic Acid in Synovial Fluid as an Indicator of Severity and Degree of Impairment in Patients Suffering from Gonarthrosis

PURPOSE OF THE STUDY Hyaluronic acid is a major component of synovial fluid and an indicator joint viscosity viscoelasticity. Decreased concentrations hyaluronic in the indicate severity osteoarthritis. The aim study was to determine evaluate correlation with osteoarthritis determined based on radiological criteria (evaluation according X-ray classification) physicochemical (measurement osmolality). MATERIAL AND METHODS A total 67 patients mean age years (35 men, = 65 years, 32 women, 68 years) clinically diagnosed were included study. divided into four groups arthrosis (from Group 1 - lowest degree disability 4 most severe arthrosis). Samples taken during knee arthroscopies or replacements. using commercially available kit sandwich ELISA principle (Teco acid, Switzerland). Osmolality measured by cryoscopic method. RESULTS average individual as follows: 1: HA 2302 mg/L, 2: 2234 3: 2300 4: 2446 mg/L. did not differ from published reference values (1500 3200 do depend age, sex, disease. who underwent arthroscopy have significantly elevated concentration compared replacements (2581 mg/l/L vs. 1763 mg/l/L, p 0.01, Mann-Whitney test). positively correlates osmotic pressure examination osmolality (r 0.29, 0.015). CONCLUSIONS are increased group replacement. correlate pressure, may therefore be additional Key words: arthrosis, replacement, osmolality.